- dhs-28 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable oxidoreductase activity. Involved in several processes, including ascaroside biosynthetic process; dauer entry; and positive regulation of developmental process. Located in peroxisome. Expressed in hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4).
- maoc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in peroxisomal membrane. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4).
- Glra1 [Search on AGR]
Homo sapiens The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]
- Adgrg6 [Search on AGR]
Homo sapiens This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
- Glrb [Search on AGR]
Homo sapiens This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- Hsd17b4 [Search on AGR]
Rattus norvegicus Enables 3-hydroxyacyl-CoA dehydratase activity; identical protein binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in cellular response to organic cyclic compound; response to steroid hormone; and response to xenobiotic stimulus. Located in peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
- Drd4 [Search on AGR]
Homo sapiens This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
- Tph1 [Search on AGR]
Rattus norvegicus Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Predicted to be located in cytoplasm. Predicted to be active in neuron projection. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-sulfonyldiphenol; 5-hydroxytryptophan.
- ADH1A [Search on AGR]
Homo sapiens This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
- Drd4 [Search on AGR]
Rattus norvegicus Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; neuronal cell body; and terminal bouton. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; 1,2-dimethylhydrazine; 3,7-dihydropurine-6-thione.