dnc-1

Caenorhabditis elegans

Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Is an ortholog of human DCTN1 (dynactin subunit 1).

Dctn1

Rattus norvegicus

Enables identical protein binding activity; microtubule binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; plasma membrane bounded cell projection organization; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within melanosome transport. Part of cytoplasmic dynein complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1); PARTICIPATES IN mitochondria transport pathway; N-cadherin signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.