hpo [Search on AGR]
Drosophila melanogaster hippo (hpo) encodes a kinase in the Salvador-Warts-Hippo pathway. It controls tissue growth by controlling cell growth, proliferation and apoptosis. It has several roles in post-mitotic cells including fate specification of photoreceptors and tiling of dendritic neurons.
Rassf6 [Search on AGR]
Homo sapiens This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Sav1 [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity; molecular adaptor activity; and protein serine/threonine kinase activator activity. Predicted to be involved in hippo signaling; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Predicted to act upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell population proliferation; and positive regulation of keratinocyte apoptotic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to human SAV1 (salvador family WW domain containing protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; thioacetamide.