srp-1

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including familial encephalopathy with neuroserpin inclusion bodies; intermediate coronary syndrome; and thrombophilia (multiple). Is an ortholog of several human genes including SERPINB1 (serpin family B member 1); SERPINB8 (serpin family B member 8); and SERPINC1 (serpin family C member 1).

adh-5

Caenorhabditis elegans

Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including AMED syndrome; alcohol dependence; and late onset Parkinson's disease. Is an ortholog of human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide).

srp-5

Caenorhabditis elegans

Enriched in PLML; PLMR; body wall muscle cell; and hypodermis based on tiling array and single-cell RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and atfs-1 based on microarray and RNA-seq studies. Is affected by Hydrolyzable Tannins; Humic Substances; and Sirolimus based on microarray studies.

srp-2

Caenorhabditis elegans

Enables cysteine-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space. Expressed in several structures, including anal sphincter muscle; cuticle; epithelial cell; intestine; and phasmid neurons. Used to study familial encephalopathy with neuroserpin inclusion bodies. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Is an ortholog of human SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2).

C15F1.14

Caenorhabditis elegans

Is affected by cep-1; adr-1; and sftb-1 based on RNA-seq studies.

C17G10.14

Caenorhabditis elegans

Is affected by adr-1; etr-1; and ogt-1 based on RNA-seq studies.

C41C4.18

Caenorhabditis elegans

Is affected by prg-1; hsf-1; and glp-1 based on RNA-seq studies.

F18C5.15

Caenorhabditis elegans

Is affected by cep-1; dlc-1; and ogt-1 based on RNA-seq studies.

F26D11.15

Caenorhabditis elegans

Is affected by cep-1; dlc-1; and glp-1 based on RNA-seq studies.

R05F9.14

Caenorhabditis elegans

Is affected by adr-1; etr-1; and ogt-1 based on RNA-seq studies.