prmn-1

Caenorhabditis elegans

Predicted to be located in membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Is an ortholog of human PROM1 (prominin 1) and PROM2 (prominin 2).

CBG04664

Caenorhabditis briggsae

Is predicted to encode a protein with the following domains: Cysteine-rich transmembrane CYSTM domain and Cysteine-rich TM module stress tolerance. Is an ortholog of C. elegans F14D7.11.

Pkhd1

Homo sapiens

The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. [provided by RefSeq, Jul 2008]

CJA08487

Caenorhabditis japonica

Is predicted to encode a protein with the following domains: Fibronectin type III; Immunoglobulin-like fold; TM proximal of protein tyrosine phosphatase, receptor type J; Fibronectin type III domain; PTPRJ, transmembrane domain; and Fibronectin type III superfamily. Is an ortholog of C. elegans C18E9.7.

C18E9.7

Caenorhabditis elegans

Enriched in arcade cell; body ganglion; excretory gland cell; pharyngeal muscle cell; and sensory neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including swsn-2.2; nuo-6; and atfs-1 based on microarray; tiling array; and RNA-seq studies. Is affected by nineteen chemicals including 1-methylnicotinamide; D-glucose; and stavudine based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Is predicted to encode a protein with the following domains: Fibronectin type III; Immunoglobulin-like fold; Extracellular Matrix Regulatory Proteins; TM proximal of protein tyrosine phosphatase, receptor type J; Fibronectin type III domain; PTPRJ, transmembrane domain; and Fibronectin type III superfamily. Is an ortholog of human TNXA (tenascin XA (pseudogene)) and TNXB (tenascin XB). Human TNXB enables collagen fibril binding activity.

CBG03226

Caenorhabditis briggsae

Is affected by Cbr-htz-1 based on RNA-seq studies. Is predicted to encode a protein with the following domains: Fibronectin type III; Immunoglobulin-like fold; TM proximal of protein tyrosine phosphatase, receptor type J; Fibronectin type III domain; PTPRJ, transmembrane domain; and Fibronectin type III superfamily. Is an ortholog of C. elegans C18E9.7.

Best3

Homo sapiens

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]

EMC10

Saccharomyces cerevisiae

Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein

SOP4

Saccharomyces cerevisiae

ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER

Gs

Drosophila melanogaster

G protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning.