Faf2

Homo sapiens

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]

Dhrs9

Mus musculus

PHENOTYPE: Mice homozygous for a null allele exhibit reduced LTB4 ad RvD1 dehydrogenase activities in the skin, lung, and tracheal microsomes. [provided by MGI curators]

Olr1877

Rattus norvegicus

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Orthologous to human OR10AD1 (olfactory receptor family 10 subfamily AD member 1); INTERACTS WITH methoxychlor; aflatoxin B1 (ortholog); benzo[a]pyrene (ortholog).

Olr1102

Rattus norvegicus

Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane. Orthologous to human OR10AD1 (olfactory receptor family 10 subfamily AD member 1); INTERACTS WITH copper atom; copper(0).

CRE17716

Caenorhabditis remanei

Is predicted to encode a protein with the following domains: YcaO domain protein; K homology domain-like, alpha/beta; OsmC/Ohr superfamily; YcaO-like domain; OsmC-like protein; YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO cyclodehydratase, C-terminal; YcaO cyclodehydratase C-terminal domain; and OsmC/Ohr family.

Mrap2

Mus musculus

PHENOTYPE: Mice homozygous for a knock-out allele develop severe obesity at a young age. Obesity develops early during ad libitum feeding before the onset of hyperphagia, persists in mutant mice pair-fed to a normal dietary intake, and is abolished only by underfeeding. [provided by MGI curators]

Lsm12

Saccharomyces cerevisiae

Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress

Psen2

Homo sapiens

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Psen1

Homo sapiens

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

E02H1.6

Caenorhabditis elegans

Predicted to enable ATP binding activity and adenylate kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation; rRNA processing; and ribosomal small subunit biogenesis. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human AK6 (adenylate kinase 6).