Mir140

Rattus norvegicus

Enables MAP kinase kinase activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of reactive oxygen species biosynthetic process; and negative regulation of toll-like receptor signaling pathway. Predicted to be part of RISC complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Nishimura type and thoracic aortic aneurysm. Orthologous to human MIR140 (microRNA 140); INTERACTS WITH aflatoxin B1; atrazine; bisphenol A.