Predicted to enable DNA polymerase binding activity. Involved in nucleotide-excision repair and regulation of DNA-templated DNA replication. Located in nucleus. Expressed in germ line. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group D2; breast cancer; and skin melanoma. Is an ortholog of human FANCD2 (FA complementation group D2).
Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Is an ortholog of human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit).
ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency; congenital disorder of glycosylation Ir; hyperprolinemia type 2; INTERACTS WITH (+)-catechin; 2,2',5,5'-tetrachlorobiphenyl; 5-aza-2'-deoxycytidine
Ionotropic receptor 25a (Ir25a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as co-receptor subunit in chemosensation and thermosensation.
Ionotropic receptor 92a (Ir92a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of ammonia and amines to mediate attraction behavior.
Ionotropic receptor 84a (Ir84a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of phenylacetic acid and controls male courtship behavior.
Ionotropic receptor 64a (Ir64a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It is part of a broad-specificity acid sensor that mediates avoidance behavior.
Ionotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit.
Ionotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids.
Predicted to enable telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Ku70:Ku80 complex. Human ortholog(s) of this gene implicated in basal cell carcinoma and squamous cell carcinoma. Is an ortholog of human XRCC6 (X-ray repair cross complementing 6).