- nkb-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Human ortholog(s) of this gene implicated in essential hypertension. Is an ortholog of several human genes including ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); ATP1B2 (ATPase Na+/K+ transporting subunit beta 2); and ATP1B3 (ATPase Na+/K+ transporting subunit beta 3).
- nkb-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Human ortholog(s) of this gene implicated in several diseases, including atrophic gastritis; autoimmune gastritis; and essential hypertension. Is an ortholog of several human genes including ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); ATP1B2 (ATPase Na+/K+ transporting subunit beta 2); and ATP1B3 (ATPase Na+/K+ transporting subunit beta 3).
- nkb-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Expressed in neurons and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including atrophic gastritis; autoimmune gastritis; and essential hypertension. Is an ortholog of several human genes including ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); ATP1B2 (ATPase Na+/K+ transporting subunit beta 2); and ATP1B3 (ATPase Na+/K+ transporting subunit beta 3).
- eat-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables P-type sodium:potassium-exchanging transporter activity. Involved in action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3).
- Calx [Search on AGR]
Drosophila melanogaster Na/Ca-exchange protein (Calx) encodes a Na-Ca exchanger involved in phototransduction and response to endoplasmic reticulum stress.
- Zmiz2 [Search on AGR]
Homo sapiens ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
- Atp [Search on AGR]
Drosophila melanogaster Na pump alpha subunit (Atpalpha) encodes an integral membrane cation antiporter protein that utilizes ATP to shuttle Na[+] and K[+] across the plasma membrane to maintain ion homeostasis.
- Dpep1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for disruption of this gene ar phenotypically normal although defects have been noted in the conversion of leukotriene D4 to leukotrience E4. [provided by MGI curators]
- Rnf14 [Search on AGR]
Homo sapiens The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]