- rad-54.L [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ATP-dependent activity, acting on DNA. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing and reciprocal meiotic recombination. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; non-Hodgkin lymphoma; and pancreatic cancer. Is an ortholog of human RAD54L (RAD54 like).
- Ptpra [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a targeted null mutation exhibit deficits in Morris water maze learning, reduced locomotor activity, and decreased anxiety. [provided by MGI curators]
- Clstn2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous KO mice display deficiency in spatial learning and memory in Morris water and Barnes maze tasks and increased locomotor activity in open field test. [provided by MGI curators]
- Fxr2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a targeted null mutation exhibit hyperactivity, impaired Morris water task performance, and reductions in prepulse inhibition, contextual conditioned fear, and sensitivity to heat stimulus. [provided by MGI curators]
- Ncam1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and neuromuscular junctions defects. Homozygotes for a null allele exhibit age-dependent retinal abnormalities. [provided by MGI curators]
- Ckmt1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele have no visual or motor impairments but display diminished open field habituation and slower spatial learning acquisition in the Morris water maze task as well as a reduced acoustic startle response, higher threshold, and lack of prepulse inhibition. [provided by MGI curators]
- Ap5z1 [Search on AGR]
Homo sapiens This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
- ipla-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Involved in intestinal lipid catabolic process and response to starvation. Located in cytoplasm. Expressed in body wall musculature; head neurons; intestine; and seam cell.
- Hr [Search on AGR]
Rattus norvegicus Enables histone deacetylase binding activity; nuclear receptor binding activity; and transcription corepressor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Part of histone deacetylase complex. Used to study focal segmental glomerulosclerosis and proteinuria. Human ortholog(s) of this gene implicated in alopecia; alopecia universalis; and atrichia with papular lesions. Orthologous to human HR (HR lysine demethylase and nuclear receptor corepressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
- ISC10 [Search on AGR]
Saccharomyces cerevisiae Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II