ZK370.4

Caenorhabditis elegans

Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including Boucher-Neuhauser syndrome; Laurence-Moon syndrome; and Oliver-McFarlane syndrome. Is an ortholog of human PNPLA6 (patatin like phospholipase domain containing 6).

M110.7

Caenorhabditis elegans

Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including Boucher-Neuhauser syndrome; Laurence-Moon syndrome; and Oliver-McFarlane syndrome. Is an ortholog of human PNPLA6 (patatin like phospholipase domain containing 6) and PNPLA7 (patatin like phospholipase domain containing 7).

Elovl6

Homo sapiens

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

egl-27

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and enzyme binding activity. Involved in several processes, including egg-laying behavior; hemidesmosome assembly; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including Y cell; intestinal cell; neurons; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Is an ortholog of human RERE (arginine-glutamic acid dipeptide repeats).

Pnpla6

Rattus norvegicus

Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process and phosphatidylcholine metabolic process. Predicted to act upstream of or within angiogenesis and animal organ morphogenesis. Predicted to be located in cytosol and membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like phospholipase domain containing 6); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine.

CCT4

Homo sapiens

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

daf-16

Caenorhabditis elegans

Enables several functions, including 14-3-3 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including regulation of dauer larval development; regulation of metabolic process; and response to stress. Located in cytosol and nucleus. Expressed in several structures, including germ cell; gonad; hypodermis; neurons; and somatic cell. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alveolar rhabdomyosarcoma; reproductive organ cancer (multiple); and rheumatoid arthritis. Is an ortholog of human FOXO4 (forkhead box O4).