hsd-3

Caenorhabditis elegans

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Is an ortholog of human SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2).

ck

Drosophila melanogaster

crinkled (ck) encodes a myosin VIIa homolog that is expected to have roles in cellular protrusion formation and cargo intracellular transport. ck hypomorphs are hearing defective and present abnormal chaetae and trichomes.

hsd-2

Caenorhabditis elegans

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Predicted to be located in membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Is an ortholog of human SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2).

Mir708

Mus musculus

PHENOTYPE: Mice homozygous for a null allele suppresses Apc^Min-induced tumorigenesis. [provided by MGI curators]

ERG26

Saccharomyces cerevisiae

C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456

hsd-1

Caenorhabditis elegans

Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity. Involved in nematode larval development and sterol biosynthetic process. Predicted to be located in membrane. Expressed in XXXL and XXXR. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Is an ortholog of human SDR42E1 (short chain dehydrogenase/reductase family 42E, member 1).

Zfp82

Mus musculus

PHENOTYPE: Mice heterozygous for a null allele exhibit increased colon tumor in Apc^Min. Mice homozygous for a conditional allele activated in the colon exhibit increased sensitivity to AOM/DSS-induced tumors. [provided by MGI curators]

ckb-2

Caenorhabditis elegans

Enables choline kinase activity. Involved in CDP-choline pathway and IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including colon adenoma; megaconial type congenital muscular dystrophy; narcolepsy; and recurrent hypersomnia. Is an ortholog of human CHKA (choline kinase alpha) and CHKB (choline kinase beta).

Khsrp

Homo sapiens

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Mir10a

Mus musculus

PHENOTYPE: Mice homozygous for a targeted deletion are viable with no observed pathologies. Mice homozygous for a knock-out allele exhibit increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas in Apc^min heterozygotes. [provided by MGI curators]