b2b464Clo

Mus musculus

PHENOTYPE: Homozygotes exhibit hypoplastic left ventricle (LV), aortic valve hypoplasia, hypoplastic aorta (Ao), hypoplastic mitral valve, aortic arch hypoplasia and atrial septal defect (ASD). [provided by MGI curators]

Arhgap19

Homo sapiens

Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

Maoa

Mus musculus

PHENOTYPE: Homozygotes for a null allele show reduced LV systolic pressure and resistance to induced cardiac stress. Males hemizygous for a spontaneous allele show intermale aggression and hypoactivity. Hemizygotes for a transgenic gene disruption show altered behavior and adrenocortical response to stress. [provided by MGI curators]

Cybb

Mus musculus

PHENOTYPE: Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses. Homozygotes for a null allele show postnatal lethality, decreased birth weight, cardiac septal and valve defects, and impaired atrioventricular cushion development. [provided by MGI curators]