nfm-1

Caenorhabditis elegans

Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including regulation of cellular localization; regulation of gliogenesis; and regulation of hippo signaling. Predicted to be located in several cellular components, including adherens junction; apical part of cell; and filopodium. Expressed in excretory gland cell; gonadal sheath cell; intestinal cell; pharyngeal muscle cell; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).

Mer

Drosophila melanogaster

Merlin (Mer) encodes a FERM domain containing protein that promotes assembly of a functional Hippo signaling complex at the apical cell cortex. It has also been associated with cell junctions and endocytic compartments.

Nf2

Rattus norvegicus

Enables beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amitrole; ammonium chloride.

Ptpn21

Homo sapiens

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]