Ndufb2

Homo sapiens

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

hp

Rattus norvegicus

Enables hemoglobin binding activity and identical protein binding activity. Involved in several processes, including response to L-ascorbic acid; response to cobalamin; and response to growth hormone. Located in blood microparticle. Used to study obesity and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); kidney failure (multiple); liver disease (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Plasmodium falciparum malaria; artery disease (multiple); gout; hemolytic anemia; and hyperglycemia. Orthologous to human HP (haptoglobin) and HPR (haptoglobin-related protein); INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Ndufa1

Homo sapiens

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]