- evl-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Is an ortholog of human CDC45 (cell division cycle 45).
- mcm-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA replication initiation and double-strand break repair via break-induced replication. Predicted to be located in nucleus. Predicted to be part of MCM complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Is an ortholog of human MCM5 (minichromosome maintenance complex component 5).
- cdc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitotic DNA replication checkpoint signaling. Located in condensed nuclear chromosome; cytoplasm; and nucleolus. Expressed in seam cell. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Is an ortholog of human CDC6 (cell division cycle 6).
- cdt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity and DNA polymerase binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Part of chromatin. Expressed in anchor cell; germ line; uterine epithelial cell; and vulD. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Is an ortholog of human CDT1 (chromatin licensing and DNA replication factor 1).
- Orc6 [Search on AGR]
Saccharomyces cerevisiae Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome
- orc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Is an ortholog of human ORC1 (origin recognition complex subunit 1).
- Orc6 [Search on AGR]
Rattus norvegicus Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acetamide.
- Cdc45 [Search on AGR]
Rattus norvegicus Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of CMG complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
- Cdc6 [Search on AGR]
Rattus norvegicus Predicted to enable DNA replication origin binding activity; chromatin binding activity; and kinase binding activity. Involved in cellular response to angiotensin; cellular response to vasopressin; and positive regulation of fibroblast proliferation. Predicted to be located in several cellular components, including intercellular bridge; nucleoplasm; and spindle. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
- Orc1 [Search on AGR]
Rattus norvegicus Enables chromatin binding activity. Involved in positive regulation of G0 to G1 transition and positive regulation of smooth muscle cell proliferation. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.