- Tl [Search on AGR]
Drosophila melanogaster Toll (Tl) encodes a transmembrane receptor that activates the Tl intracellular signaling pathway upon binding the ligand encoded by spz. It is involved in dorso-ventral embryonic patterning and immunity.
- Tehao [Search on AGR]
Drosophila melanogaster Tehao (Tehao) encodes a homologue of the receptor encoded by Tl. It is involved in the Toll signaling pathway and innate immune response.
- tey [Search on AGR]
Drosophila melanogaster teyrha-meyrha (tey) encodes a nuclear protein that regulates neuromuscular target specificity partly by repressing the expression of Tl in specific muscles.
- snk [Search on AGR]
Drosophila melanogaster snake (snk) encodes a secreted serine protease. It is a member of the protease cascade that generates the ligand that activates the receptor encoded by Tl. It contributes to establishment of the dorsal-ventral embryonic axis.
- gd [Search on AGR]
Drosophila melanogaster gastrulation-defective (gd) encodes a secreted serine protease. It is a member of the protease cascade that generates the ligand that activates the receptor encoded by Tl. It contributes to establishment of the dorsal-ventral embryonic axis.
- H2-T3 [Search on AGR]
Mus musculus PHENOTYPE: This locus contains the sole gene encoding the thymic leukemia antigen or TL antigen in "b haplotype" mice such as C57BL/6. Mice homozygous for a targeted knock-out are viable with normal reproduction. [provided by MGI curators]
- MstProx [Search on AGR]
Drosophila melanogaster MstProx (MstProx) encodes a protein with an intracellular Toll/interleukin-1 receptor domain and extracellular Leucine-rich repeats. Although also designated as "Toll-3" and related to Tl, it is not known to activate the canonical Toll signaling pathway or antimicrobial response.
- wek [Search on AGR]
Drosophila melanogaster weckle (wek) encodes a zinc finger adaptor protein of the Toll signaling pathway in embryonic dorsoventral patterning. It facilitates the recruitment of the product of Myd88 to the receptor encoded by Tl. However, the product of wek is dispensable for Toll-mediated innate immunue response.
- Myd88 [Search on AGR]
Drosophila melanogaster Myd88 (Myd88) encodes an adaptor protein involved in in the Toll pathway functioning downstream of the product of Tl and upstream of the product of tub. Toll pathway is a signaling cascade that plays a key role in various developmental and immune processes, notably embryonic dorsoventral patterning and regulation of antimicrobial peptides.
- H2-T18 [Search on AGR]
Mus musculus PHENOTYPE: This locus contains the coding member of a gene pair encoding the thymic leukemia antigen or TL antigen in "d haplotype" mice such as BALB/c. The other member of this gene pair, H2-T3<sup>d</sup>, is a pseudogene. [provided by MGI curators]