lad-2

Caenorhabditis elegans

Enables semaphorin receptor activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and regulation of axon guidance. Located in plasma membrane. Expressed in lumbar neurons and nerve ring neurons. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; MASA syndrome; carcinoma (multiple); and pheochromocytoma. Is an ortholog of human L1CAM (L1 cell adhesion molecule).

gtl-2

Caenorhabditis elegans

Predicted to enable monoatomic cation channel activity. Predicted to be involved in metal ion transport and monoatomic cation transmembrane transport. Located in basal plasma membrane. Expressed in excretory canal; excretory cell; hypodermis; pharyngeal muscle cell; and pharynx. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7).

sax-7

Caenorhabditis elegans

Enables ankyrin binding activity. Involved in several processes, including cell development; establishment of mitotic spindle orientation; and regulation of cell morphogenesis. Located in several cellular components, including axolemma; lateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including gonad; neurons; pharynx; somatic nervous system; and vulval cell. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule).

L1cam

Rattus norvegicus

Enables PDZ domain binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to ethanol; and neuron differentiation. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse. Used to study hydrocephalus. Biomarker of anxiety disorder; depressive disorder; and hypothyroidism. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.