This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]
This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]
MAGE (MAGE) encodes a component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes.
Is predicted to encode a protein with the following domains: Melanoma-associated antigen; MAGE homology domain; and MAGE homology domain, winged helix WH2 motif. Is an ortholog of C. elegans C39D10.11.
Is predicted to encode a protein with the following domains: Melanoma-associated antigen; MAGE homology domain; and MAGE homology domain, winged helix WH2 motif. Is an ortholog of B. malayi Bm3956.