- Set8 [Search on AGR]
Drosophila melanogaster SET domain containing 8 (Set8) encodes the histone methyltransferase that controls lysine20 monomethylation of the product of His4. This histone mark is essential for normal progression through the cell cycle.
- Kdm1b [Search on AGR]
Homo sapiens Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
- btz [Search on AGR]
Drosophila melanogaster barentsz (btz) encodes a component of the exon junction complex that is recruited to spliced mRNAs to mark where introns have been removed. It is required for the posterior localization of osk mRNA.
- jmjd-3.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex.
- jmjd-3.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex.
- cid [Search on AGR]
Drosophila melanogaster centromere identifier (cid) encodes a centromere-specific histone H3 variant. The nucleosomes containing the product of cid function as an epigenetic mark for centromere identity, and initiate an assembly process that recruits additional centromere proteins (like the product of Cenp-C) as well as kinetochore proteins at the start of mitotic and meiotic divisions.
- Skel [Search on AGR]
Drosophila melanogaster Skeletor (Skel) encodes a protein that localizes to chromosomes at interphase and interacts directly with the product of Chro to mark regions of open chromatin. It forms part of a matrix embedding the microtubule spindle apparatus, which is important for normal cell cycle progression and functions as a spatial regulator of cell cycle factors.
- JIL-1 [Search on AGR]
Drosophila melanogaster JIL-1 kinase (JIL-1) encodes a Serine/Threonine tandem kinase that phosphorylates the Serine 10 residue of the product of His3. A key function of the product of JIL-1 is to antagonize heterochromatization and to regulate levels of gene expression by controlling the distribution of the Lysine 9 dimethylation mark of the epigenetic histone encoded by His3.
- utx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Involved in cell fate specification and programmed cell death. Part of MLL3/4 complex. Expressed in several structures, including germ line; gonad; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; breast cancer (multiple); and carcinoma (multiple). Is an ortholog of human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).