nefr-1

Caenorhabditis elegans

Predicted to enable kinase activity. Expressed in lateral ganglion; nerve ring; and neurons. Used to study Charcot-Marie-Tooth disease.

T19B10.5

Caenorhabditis elegans

Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Is an ortholog of human AHNAK2 (AHNAK nucleoprotein 2) and PRX (periaxin).

mtm-5

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B2 and Charcot-Marie-Tooth disease type 4B3. Is an ortholog of human SBF1 (SET binding factor 1) and SBF2 (SET binding factor 2).

F36G3.3

Caenorhabditis elegans

Predicted to enable zinc ion binding activity. Predicted to be located in endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Is an ortholog of human LITAF (lipopolysaccharide induced TNF factor).

SBF2-AS1

Homo sapiens

ASSOCIATED WITH Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 4; Charcot-Marie-Tooth disease type 4B2; INTERACTS WITH 2-hydroxypropanoic acid; aflatoxin B1; butanal

yars-1

Caenorhabditis elegans

Predicted to enable ATP binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in tyrosyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Is an ortholog of human YARS1 (tyrosyl-tRNA synthetase 1).

morc-1

Caenorhabditis elegans

Enables topological DNA co-entrapment activity. Involved in DNA topological change. Located in nuclear body. Expressed in somatic cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Is an ortholog of human MORC1 (MORC family CW-type zinc finger 1).

spp-11

Caenorhabditis elegans

Enriched in ABprpapppa; PVDL; anterior arcade cell; and dopaminergic neurons based on tiling array and single-cell RNA-seq studies. Is affected by several genes including nuo-6; atf-7; and mrps-5 based on tiling array; microarray; and RNA-seq studies. Is affected by eight chemicals including glycine; Chlorpyrifos; and single-walled carbon nanotube based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Is predicted to encode a protein with the following domains: Saposin B type domain and Saposin-like. Is an ortholog of human PRX (periaxin).

F21D5.5

Caenorhabditis elegans

Enables double-stranded DNA binding activity. Predicted to be involved in DNA repair. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2; ataxia-oculomotor apraxia type 4; and microcephaly, seizures, and developmental delay. Is an ortholog of human PNKP (polynucleotide kinase 3'-phosphatase).

ATP1A1-AS1

Homo sapiens

ASSOCIATED WITH Charcot-Marie-Tooth Disease Type 2A2; Charcot-Marie-Tooth disease type 2DD; genetic disease; INTERACTS WITH 17beta-estradiol; aristolochic acid A; arsane