Enables DNA endonuclease activity. Involved in several processes, including DNA metabolic process; cellular response to hydroxyurea; and response to radiation. Located in several cellular components, including condensed chromosome; midbody; and mitotic spindle midzone. Expressed in embryonic cell. Is an ortholog of human ANKLE1 (ankyrin repeat and LEM domain containing 1).
Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including microtubule organizing center organization; nuclear membrane reassembly; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3).