tif-1A

Caenorhabditis elegans

Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to be involved in transcription initiation at RNA polymerase I promoter. Predicted to be located in nucleus. Is an ortholog of human RRN3 (RRN3 homolog, RNA polymerase I transcription factor).

rpoa-49

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and transcription elongation by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be part of RNA polymerase I complex. Is an ortholog of human POLR1E (RNA polymerase I subunit E).

F23H11.2

Caenorhabditis elegans

Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and nucleolar large rRNA transcription by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be part of RNA polymerase I core factor complex and RNA polymerase transcription factor SL1 complex.

rpoa-12

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is an ortholog of human POLR1H (RNA polymerase I subunit H).

Y48E1B.3

Caenorhabditis elegans

Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly. Predicted to be located in fibrillar center.

rpoa-1

Caenorhabditis elegans

Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Is an ortholog of human POLR1A (RNA polymerase I subunit A).

ndua-8

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Is an ortholog of human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8).

ndub-3

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Alzheimer's disease and nuclear type mitochondrial complex I deficiency 25. Is an ortholog of human NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3).

meic-1

Caenorhabditis elegans

Predicted to be involved in female meiosis I; mRNA stabilization; and male meiosis I. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human MEIOC (meiosis specific with coiled-coil domain).

nduf-9

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex I assembly and ubiquinone-6 biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Expressed in head and tail. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Is an ortholog of human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9).