MSH2-OT1

Homo sapiens

ASSOCIATED WITH Lynch syndrome; Lynch syndrome 1; Pitt-Hopkins-like syndrome 2; INTERACTS WITH perfluorooctanoic acid

mlh-1

Caenorhabditis elegans

Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); carcinoma (multiple); and cervix uteri carcinoma in situ. Is an ortholog of human MLH1 (mutL homolog 1).

Rsph10b

Homo sapiens

ENCODES a protein that exhibits kinase activity (inferred); INVOLVED IN phosphorylation (inferred); ASSOCIATED WITH Lynch syndrome; Lynch syndrome 1; FOUND IN 9+2 motile cilium (ortholog); INTERACTS WITH acrylamide; afimoxifene; aristolochic acid A

LINC02898

Homo sapiens

ASSOCIATED WITH Lynch syndrome; Neurodevelopmental Disorders; INTERACTS WITH lipopolysaccharide; rifampicin; S-(1,2-dichlorovinyl)-L-cysteine

SOS1-IT1

Homo sapiens

ASSOCIATED WITH Lynch syndrome; Neurodevelopmental Disorders; RASopathy; INTERACTS WITH N-methyl-4-phenylpyridinium

msh-2

Caenorhabditis elegans

Predicted to enable double-strand/single-strand DNA junction binding activity and mismatched DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of DNA repeat elements; and mismatch repair. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); carcinoma (multiple); and cervix uteri carcinoma in situ. Is an ortholog of human MSH2 (mutS homolog 2).

Aste1

Rattus norvegicus

Predicted to enable nuclease activity. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to human ASTE1 (asteroid homolog 1); INTERACTS WITH 17beta-estradiol; benzo[a]pyrene; bisphenol A.

oat-1

Caenorhabditis elegans

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Is an ortholog of several human genes including SLC22A17 (solute carrier family 22 member 17); SLC22A6 (solute carrier family 22 member 6); and SLC22A8 (solute carrier family 22 member 8).

M01A12.4

Caenorhabditis elegans

Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of human PTPRR (protein tyrosine phosphatase receptor type R).

Rnasel

Rattus norvegicus

Enables RNA nuclease activity and rRNA binding activity. Involved in rRNA processing. Located in nuclear matrix. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L); PARTICIPATES IN hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.