- Naxe [Search on AGR]
Rattus norvegicus Enables NAD(P)HX epimerase activity. Involved in metabolite repair. Predicted to be located in several cellular components, including cell body; cilium; and extracellular space. Predicted to be active in mitochondrion. Orthologous to human NAXE (NAD(P)HX epimerase); INTERACTS WITH acetamide; bisphenol A; C60 fullerene.
- Yjefn3 [Search on AGR]
Rattus norvegicus Predicted to enable NAD(P)HX epimerase activity. Predicted to be active in mitochondrion. Orthologous to human YJEFN3 (YjeF N-terminal domain containing 3); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
- Yjefn3 [Search on AGR]
Homo sapiens Predicted to enable NAD(P)HX epimerase activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; membrane raft distribution; and negative regulation of angiogenesis. [provided by Alliance of Genome Resources, Apr 2025]
- Naxd [Search on AGR]
Rattus norvegicus Enables ATP-dependent NAD(P)H-hydrate dehydratase activity. Involved in metabolite repair. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrion. Orthologous to human NAXD (NAD(P)HX dehydratase); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
- Slurp2 [Search on AGR]
Homo sapiens This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]
- Lypd6 [Search on AGR]
Homo sapiens Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
- Lynx1 [Search on AGR]
Homo sapiens This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent excessive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]
- Klf1 [Search on AGR]
Homo sapiens This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]