rskn-1

Caenorhabditis elegans

Predicted to enable ribosomal protein S6 kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome and non-syndromic X-linked intellectual disability 19. Is an ortholog of several human genes including RPS6KA1 (ribosomal protein S6 kinase A1); RPS6KA2 (ribosomal protein S6 kinase A2); and RPS6KA3 (ribosomal protein S6 kinase A3).

Bend2

Rattus norvegicus

ASSOCIATED WITH autistic disorder (ortholog); Coffin-Lowry syndrome (ortholog); developmental and epileptic encephalopathy 2 (ortholog); INTERACTS WITH arsane (ortholog); arsenic atom (ortholog); benzo[a]pyrene (ortholog)

Rps6ka3

Mus musculus

PHENOTYPE: Homozygotes/hemizygotes are a model for Coffin-Lowry Syndrome. One allele shows impaired osteoblast function with reduced long and craniofacial bones. Another allele shows infertility, lipodystrophy, impaired glycogen, glucose, and insulin metabolism, and impaired memory and coordination. [provided by MGI curators]

spk-1

Caenorhabditis elegans

Enables protein serine/threonine kinase activity. Involved in embryo development. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including gonad and tail. Is an ortholog of human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3).

Rps6ka3

Homo sapiens

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

Rps6ka3

Rattus norvegicus

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein kinase binding activity; and ribosomal protein S6 kinase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; response to lipopolysaccharide; and toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3); PARTICIPATES IN platelet-derived growth factor signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; long term potentiation; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.