lrx-1

Caenorhabditis elegans

Enriched in mc3; pharynx; pm1; pm2; and pm7 based on microarray and single-cell RNA-seq studies. Is affected by several genes including cyc-1; swsn-9; and nuo-6 based on microarray and RNA-seq studies. Is affected by eighteen chemicals including multi-walled carbon nanotube; D-glucose; and stavudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein receptor domain class A; Low-density lipoprotein receptor; and LDL receptor-like superfamily.

F32E10.8

Caenorhabditis elegans

Enriched in GLR; MSpppaaa; coelomocyte; head mesodermal cell; and mu_int_L based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including etr-1; rsr-2; and hpl-2 based on tiling array and RNA-seq studies. Is affected by six chemicals including Zidovudine; rifampin; and Sirolimus based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein receptor domain class A; Low-density lipoprotein receptor; and LDL receptor-like superfamily.

grl-23

Caenorhabditis elegans

Predicted to be located in cytoplasm.

gldi-2

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autistic disorder; and cerebellar ataxia, mental retardation and dysequlibrium syndrome. Is an ortholog of human LDLR (low density lipoprotein receptor); LRP8 (LDL receptor related protein 8); and VLDLR (very low density lipoprotein receptor).

lpr-7

Caenorhabditis elegans

Predicted to be located in membrane.

nac-1

Caenorhabditis elegans

Enables low-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transport. Predicted to be located in plasma membrane. Expressed in alimentary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Is an ortholog of human SLC13A2 (solute carrier family 13 member 2) and SLC13A5 (solute carrier family 13 member 5).

lrpc-1

Caenorhabditis elegans

Predicted to enable chitin binding activity. Predicted to be located in extracellular region.

repro53

Mus musculus

PHENOTYPE: Homozygotes for this ENU-induced mutation exhibit male reproductive abnormalities including infertility, low sperm concentration, low sperm motility and low seminal vesicle weight. [provided by MGI curators]

grl-25

Caenorhabditis elegans

Predicted to be located in cytoplasm. Expressed in intestine; nervous system; and reproductive system.

repro51

Mus musculus

PHENOTYPE: Homozygotes for this ENU-induced mutation exhibit male reproductive abnormalities including infertility, low sperm concentration, abnormal sperm head and tail morphology, low sperm motility, and low seminal vesicle weight. [provided by MGI curators]