Dlish

Drosophila melanogaster

Dachs ligand with SH3s (Dlish) encodes an adapter protein that can bind to the products of dachs, ds, and ft. It is required for the normal growth of wings and legs via Dachsous-Fat signaling.

lft

Drosophila melanogaster

lowfat (lft) encodes a protein that influences Dachsous-Fat signaling by elevating levels of the products of ds and ft at apical membranes. Mutation of lft causes mild planar cell polarity and growth phenotypes.

fj

Drosophila melanogaster

four-jointed (fj) encodes a type II transmembrane kinase. Through phosphorylation of the atypical cadherins encoded by ft and ds, it regulates control of planar polarity in epithelia and also growth via the Hippo/Warts pathway.

ft

Drosophila melanogaster

fat (ft) is a tumor suppressor gene that encodes a large cadherin family transmembrane protein. It functions in the Hippo signaling pathway (as a receptor) and the Dachsous-Fat planar cell polarity pathway (as a transmembrane component).

kug

Drosophila melanogaster

kugelei (kug) (also known as Fat2 or Fat-like) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication. It is related to the product of ft and its roles include control of planar cell polarity, collective cell migration and morphogenesis.