- gsp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine phosphatase activity. Involved in negative regulation of protein phosphorylation and positive regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Expressed in oocyte. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Is an ortholog of human PPP1CB (protein phosphatase 1 catalytic subunit beta).
- Sagg [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced mutation exhibit loose skin. [provided by MGI curators]
- Irak3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age. [provided by MGI curators]
- Oc90 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a null allele exhibit reduced, enlarged, and loose otoliths, and thin cupula, saccule, utricle and tectorial membranes. [provided by MGI curators]
- Loxl1 [Search on AGR]
Mus musculus PHENOTYPE: Elastic fiber homeostasis is disrupted in homozygous mutant mice, resulting in loose skin, abnormal lung morphology, intestinal defects, and post partum uterine prolapse. [provided by MGI curators]
- Fbln5 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous inactivation of this locus impairs elastic fiber development. Mutant mice exhibit loose skin, lung abnormalities leading to emphysema, and cardiovascular defects affecting the aorta. [provided by MGI curators]
- Atox1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a targeted null mutation have impaired intracellular copper trafficking and exhibit high postnatal mortality, retarded growth, hypoactivity, loose skin, hypopigmentation, and seizures. [provided by MGI curators]
- Krt5 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract. [provided by MGI curators]
- Aurkc [Search on AGR]
Mus musculus PHENOTYPE: Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads. [provided by MGI curators]
- solo [Search on AGR]
Drosophila melanogaster sisters on the loose (solo) encodes a chromosome protein involved in the meiotic sister chromatid cohesion pathway. It is required for sister centromere cohesion in both male and female meiosis and for maintenance of synaptonemal complexes and normal levels of homolog crossing-over in female meiosis.