- gsp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein serine/threonine phosphatase activity. Involved in negative regulation of protein phosphorylation and positive regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Expressed in oocyte. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Is an ortholog of human PPP1CB (protein phosphatase 1 catalytic subunit beta).
- irk-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inward rectifier potassium channel activity. Involved in short-term memory. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in HSNL; HSNR; and sensory neurons. Human ortholog(s) of this gene implicated in several diseases, including Bartter disease type 2; EAST syndrome; and Leber congenital amaurosis 16. Is an ortholog of human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10); KCNJ13 (potassium inwardly rectifying channel subfamily J member 13); and KCNJ15 (potassium inwardly rectifying channel subfamily J member 15).
- Sagg [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced mutation exhibit loose skin. [provided by MGI curators]
- irk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables inward rectifier potassium channel activity. Involved in regulation of G protein-coupled receptor signaling pathway and regulation of egg-laying behavior. Located in neuron projection and neuronal cell body. Expressed in egg-laying apparatus; gonad; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Is an ortholog of several human genes including KCNJ2 (potassium inwardly rectifying channel subfamily J member 2); KCNJ3 (potassium inwardly rectifying channel subfamily J member 3); and KCNJ4 (potassium inwardly rectifying channel subfamily J member 4).
- Irak3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age. [provided by MGI curators]