lim-7

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; head morphogenesis; and pharynx development. Located in nucleus. Expressed in several structures, including body wall musculature; head neurons; lumbar neurons; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including atrial fibrillation; diabetes mellitus (multiple); and heart septal defect (multiple). Is an ortholog of human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2).

lim-8

Caenorhabditis elegans

Enables protein domain specific binding activity. Predicted to be involved in positive regulation of stress fiber assembly and regulation of focal adhesion assembly. Located in M band. Expressed in excretory canal; head neurons; non-striated muscle; spermatheca; and vulva. Is an ortholog of human LIMCH1 (LIM and calponin homology domains 1).

lim-9

Caenorhabditis elegans

Enables protein domain specific binding activity. Located in M band. Expressed in several structures, including body wall musculature; excretory canal; non-striated muscle; spermatheca; and vulva. Is an ortholog of human FHL2 (four and a half LIM domains 2).

lim-4

Caenorhabditis elegans

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of transcription by RNA polymerase II; and serotonin biosynthetic process. Located in nucleus. Expressed in several structures, including ABalpppppa; head muscle; head neurons; lumbar neurons; and somatic nervous system. Is an ortholog of human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8).

ddo-2

Caenorhabditis elegans

Enables D-aspartate oxidase activity and D-glutamate oxidase activity. Involved in aspartate catabolic process. Predicted to be located in peroxisomal matrix. Expressed in body wall musculature; intestinal cell; and pharyngeal muscle cell.

daao-1

Caenorhabditis elegans

Enables D-amino-acid oxidase activity. Predicted to be involved in D-amino acid catabolic process and digestion. Predicted to be located in cytoplasm. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human DDO (D-aspartate oxidase).

ddo-1

Caenorhabditis elegans

Enables D-aspartate oxidase activity; D-glutamate oxidase activity; and FAD binding activity. Predicted to be involved in D-amino acid catabolic process. Predicted to be located in peroxisomal matrix. Expressed in hypodermis and intestinal cell. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human DAO (D-amino acid oxidase).

lim-6

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; system process; and uterus morphogenesis. Located in nucleus. Expressed in several structures, including amphid neurons; excretory system; hermaphrodite gonad; nerve ring neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7 and nail-patella syndrome. Is an ortholog of human LMX1B (LIM homeobox transcription factor 1 beta).

F32D8.12

Caenorhabditis elegans

Predicted to enable D-lactate dehydrogenase (cytochrome) activity; D-lactate dehydrogenase activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in lactate catabolic process. Predicted to be located in mitochondrion. Is an ortholog of human LDHD (lactate dehydrogenase D).

tag-273

Caenorhabditis elegans

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be located in actin cytoskeleton and plasma membrane. Is an ortholog of human LIMA1 (LIM domain and actin binding 1).