chk-2

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Expressed in germline blastomere. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).

chkr-1

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2).

ENA1

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance

ENA2

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux

F43B10.1

Caenorhabditis elegans

Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Is an ortholog of human PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha) and PPP2R3B (protein phosphatase 2 regulatory subunit B''beta).

sto-3

Caenorhabditis elegans

Predicted to be located in plasma membrane. Expressed in RIB; ray neuron type B; and tail.

ldh-1

Caenorhabditis elegans

Enables L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to be located in mitochondrion. Expressed in tail. Is an ortholog of several human genes including LDHA (lactate dehydrogenase A); LDHB (lactate dehydrogenase B); and LDHC (lactate dehydrogenase C).

tbcb-1

Caenorhabditis elegans

Predicted to be located in cytoplasm and microtubule. Is an ortholog of human TBCB (tubulin folding cofactor B).

F52D10.2

Caenorhabditis elegans

Expressed in head and tail. Is an ortholog of human FAM43B (family with sequence similarity 43 member B).

srp-8

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Is an ortholog of several human genes including SERPINB1 (serpin family B member 1); SERPINB8 (serpin family B member 8); and SERPINB9 (serpin family B member 9).