- FUT3 [Search on AGR]
Homo sapiens The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
- SNCA-AS1 [Search on AGR]
Homo sapiens ASSOCIATED WITH Lewy bodies; Lewy body dementia; Parkinson's disease
- gba-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Human ortholog(s) of this gene implicated in several diseases, including Gaucher's disease (multiple); Lewy body dementia; and Netherton syndrome. Is an ortholog of human GBA1 (glucosylceramidase beta 1).
- gba-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Human ortholog(s) of this gene implicated in several diseases, including Gaucher's disease (multiple); Lewy body dementia; and Netherton syndrome. Is an ortholog of human GBA1 (glucosylceramidase beta 1).
- Fut7 [Search on AGR]
Homo sapiens The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
- fut-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and glycoprotein 3-alpha-L-fucosyltransferase activity. Involved in carbohydrate biosynthetic process and fucosylation. Predicted to be located in Golgi membrane. Expressed in chemosensory neurons; pharyngeal-intestinal valve; rectal valve cell; and retrovesicular ganglion. Is an ortholog of human FUT3 (fucosyltransferase 3 (Lewis blood group)); FUT5 (fucosyltransferase 5); and FUT6 (fucosyltransferase 6).
- Fbxo7 [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of mitophagy. Predicted to be located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
- Muc5ac [Search on AGR]
Homo sapiens Predicted to be an extracellular matrix structural constituent. Involved in phosphatidylinositol-mediated signaling. Located in cytoplasm; extracellular space; and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple). [provided by Alliance of Genome Resources, Apr 2022]
- Chchd2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous knockout affects autophagy and mitochondrial morphology and promotes Lewy body formation in the brain, resulting in impaired motor coordination in old mice. [provided by MGI curators]
- Fut4 [Search on AGR]
Homo sapiens The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]