Enables mitogen-activated protein kinase kinase kinase binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including gonad morphogenesis; inductive cell migration; and signal transduction. Predicted to be located in cytoplasm. Expressed in neurons; pharynx; and ventral nerve cord.
Involved in motor neuron axon guidance. Predicted to be located in cytoskeleton. Expressed in neurons. Is an ortholog of human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2).
Enables protein domain specific binding activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan. Located in nucleus. Part of transcription regulator complex. Expressed in tail neurons. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is an ortholog of human MAX (MYC associated factor X).