Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).
Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection; plasma membrane; and synapse. Predicted to be part of acetylcholine-gated channel complex. Expressed in several structures, including DD neuron; anal depressor muscle; ganglia; head neurons; and uterine-vulval cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit).
Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.
Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).
Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).
Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).
Enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in cytoplasm. Expressed in hypodermis and neurons. Is an ortholog of human MSRA (methionine sulfoxide reductase A).