- C30B5.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in endosome. Is an ortholog of human LEPROT (leptin receptor overlapping transcript) and LEPROTL1 (leptin receptor overlapping transcript like 1).
- Adig [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced high fat diet-induced fat and weight gain, decreased fat mass-adjusted leptin levels, and reduced leptin secretion in adipose explants. [provided by MGI curators]
- Prlh [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mutation of this gene results in polyphagia; late-onset obesity and adiposity; increase in circulating insulin, leptin, and triglyceride levels; impaired glucose tolerance and insulin resistance; and attenuated responses to the anorexigenic signals cholecystokinin and leptin. [provided by MGI curators]
- Retnla [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice have decreased circulating levels of leptin and are resistant to induced colitis. [provided by MGI curators]
- Rsc1a1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice develop obesity and exhibit increased serum cholesterol and leptin levels and increased absorption of D-glucose in the small intestine. [provided by MGI curators]
- Lepr [Search on AGR]
Rattus norvegicus Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of behavior; and positive regulation of cell communication. Located in extracellular space. Used to study several diseases, including chronic kidney disease; congestive heart failure (multiple); glucose metabolism disease (multiple); obesity; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor); PARTICIPATES IN leptin system pathway; altered leptin system pathway; obesity pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
- Plaat3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, decreased susceptibility to diet- or leptin deficiency-induced obesity, hepatic steatosis and altered glucose homeostasis. [provided by MGI curators]
- Inppl1 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mice display decreased postnatal growth, decreased circulating levels of leptin, free fatty acids, triglycerides, and total cholesterol, and resistance to diet-induced obesity. [provided by MGI curators]
- Plekhn1 [Search on AGR]
Mus musculus PHENOTYPE: Older male mice homozygous for a knock-out allele develop obesity associated with increased epididymal fat pad and liver weight, hyperphagia and increased circulating leptin levels. [provided by MGI curators]