F09E5.11

Caenorhabditis elegans

Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in endomembrane system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIp. Is an ortholog of human TMEM199 (transmembrane protein 199).

F02E9.1

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum.

irk-3

Caenorhabditis elegans

Predicted to enable inward rectifier potassium channel activity. Involved in short-term memory. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in HSNL; HSNR; and sensory neurons. Human ortholog(s) of this gene implicated in several diseases, including Bartter disease type 2; EAST syndrome; and Leber congenital amaurosis 16. Is an ortholog of human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10); KCNJ13 (potassium inwardly rectifying channel subfamily J member 13); and KCNJ15 (potassium inwardly rectifying channel subfamily J member 15).

irk-1

Caenorhabditis elegans

Enables inward rectifier potassium channel activity. Involved in regulation of G protein-coupled receptor signaling pathway and regulation of egg-laying behavior. Located in neuron projection and neuronal cell body. Expressed in egg-laying apparatus; gonad; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Is an ortholog of several human genes including KCNJ2 (potassium inwardly rectifying channel subfamily J member 2); KCNJ3 (potassium inwardly rectifying channel subfamily J member 3); and KCNJ4 (potassium inwardly rectifying channel subfamily J member 4).

cyp-31A5

Caenorhabditis elegans

Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Is an ortholog of human CYP4V2 (cytochrome P450 family 4 subfamily V member 2).

cyp-32A1

Caenorhabditis elegans

Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Is an ortholog of human CYP4V2 (cytochrome P450 family 4 subfamily V member 2).

cyp-29A4

Caenorhabditis elegans

Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Is an ortholog of human CYP4V2 (cytochrome P450 family 4 subfamily V member 2).

cyp-29A3

Caenorhabditis elegans

Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Is an ortholog of human CYP4V2 (cytochrome P450 family 4 subfamily V member 2).

H14A12.3

Caenorhabditis elegans

Predicted to be located in nuclear envelope. Predicted to be part of RAVE complex. Human ortholog(s) of this gene implicated in Kohlschutter-Tonz syndrome. Is an ortholog of human ROGDI (rogdi atypical leucine zipper).

F32D8.5

Caenorhabditis elegans

Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Is an ortholog of human TMEM70 (transmembrane protein 70).