C56E6.7

Caenorhabditis elegans

Enriched in ADE sheath cell; IL socket cell; and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including mrps-5; lpd-3; and clk-1 based on microarray and RNA-seq studies.

algn-9

Caenorhabditis elegans

Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Is an ortholog of human ALG9 (ALG9 alpha-1,2-mannosyltransferase).

Il17rc

Homo sapiens

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

F16B12.5

Caenorhabditis elegans

Enriched in ABalpapaap; ABarappaap; IL socket cell; and M3L based on single-cell RNA-seq studies. Is affected by several genes including mut-2; drh-3; and rrf-2 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including rifampin; Psoralens; and Sirolimus based on RNA-seq and microarray studies.

argk-1

Caenorhabditis elegans

Predicted to enable kinase activity. Involved in ATP metabolic process and generation of precursor metabolites and energy. Predicted to be located in extracellular space. Expressed in IL socket cell and OL socket cell. Is an ortholog of several human genes including CKB (creatine kinase B); CKM (creatine kinase, M-type); and CKMT1B (creatine kinase, mitochondrial 1B).

Casp4

Mus musculus

PHENOTYPE: Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS. [provided by MGI curators]

ZK688.1

Caenorhabditis elegans

Enriched in IL socket cell; arc ant V; dopaminergic neurons; and mechanosensory neurons based on tiling array and single-cell RNA-seq studies. Is affected by several genes including etr-1; ash-2; and rrf-3 based on microarray and RNA-seq studies. Is affected by six chemicals including rifampin; allantoin; and Chlorpyrifos based on RNA-seq and microarray studies.

Wdr82

Homo sapiens

TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

Il18rap

Mus musculus

PHENOTYPE: Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18. [provided by MGI curators]

pugs-7

Caenorhabditis elegans

Enriched in IL socket cell; arc ant V; hyp3; and neurons based on tiling array; single-cell RNA-seq; and RNA-seq studies. Is affected by several genes including drh-3; rrf-3; and mrps-5 based on microarray and RNA-seq studies. Is affected by methylmercuric chloride; Colistin; and Sirolimus based on microarray studies. Is predicted to encode a protein with the following domain: C6 domain.