- zmp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24).
- aff-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in regulation of egg-laying behavior and syncytium formation by plasma membrane fusion. Located in plasma membrane. Expressed in anchor cell; egg-laying apparatus; epithelial cell; neurons; and pharyngeal muscle cell.
- Wdr82 [Search on AGR]
Homo sapiens TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
- Gipc1 [Search on AGR]
Homo sapiens GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
- Setd1b [Search on AGR]
Homo sapiens SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
- cdh-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable structural molecule activity. Involved in basement membrane disassembly and nematode male tail tip morphogenesis. Located in basement membrane; cytoplasm; and plasma membrane. Expressed in several structures, including HSN; VC neuron; anchor cell; epithelial cell; and ventral nerve cord.
- Aca71 [Search on AGR]
Mus musculus PHENOTYPE: Visualization with the Zeiss AC-Master reveals that lenses of mice with this mutation are smaller than normal. [provided by MGI curators]
- hlh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein dimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of metabolic process; and sex differentiation. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including distal tip cell; enteric muscle; lateral ganglion; ray precursor cell; and terminal bulb. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Fuchs' endothelial dystrophy; Pitt-Hopkins syndrome; and agammaglobulinemia (multiple). Is an ortholog of human TCF12 (transcription factor 12); TCF3 (transcription factor 3); and TCF4 (transcription factor 4).
- unc-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable signaling receptor binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis. Located in axon; basement membrane; and cytoplasm. Expressed in several structures, including P1; VA12; accessory cell; interneuron; and somatic neurons. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Is an ortholog of human NTN1 (netrin 1).