- Mst1 [Search on AGR]
Saccharomyces cerevisiae Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr
- PGRP-LE [Search on AGR]
Drosophila melanogaster Peptidoglycan recognition protein LE (PGRP-LE) encodes an intracellular protein that interacts with DAP-type peptidoglycan to activate the immune deficiency pathway, notably in the midgut.
- Listericin [Search on AGR]
Drosophila melanogaster Listericin (Listericin) encodes an antibacterial protein whose induction is cooperatively regulated by the product of PGRP-LE and the JAK-STAT pathway.
- Sgpp1 [Search on AGR]
Homo sapiens Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
- Tpe1 [Search on AGR]
Mus musculus PHENOTYPE: This locus controls electrophoretic variation of a protein in tears. A co-dominant fast band is seen in C3H/He, CBA/N, IC/Le, KK, SWM/MS, WB/Re and WC/Re; a co-dominant slow band in DBA/1, DBA/2, C57L, NZB, NZW and SM; and a recessive null allele (no band) in BALB/c, A/He, AKR, CL/Fr, DDD and NC. [provided by MGI curators]
- IFNL4 [Search on AGR]
Homo sapiens This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017]