- CYLD-AS1 [Search on AGR]
Homo sapiens ASSOCIATED WITH Blau syndrome; Brooke-Spiegler syndrome; Chediak-Higashi syndrome
- CYLD-AS2 [Search on AGR]
Homo sapiens ASSOCIATED WITH Brooke-Spiegler syndrome; Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis-8; genetic disease
- cyld-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein K63-linked deubiquitination. Predicted to be located in cytosol. Expressed in several structures, including arcade cell; pharyngeal cell; pharyngeal-intestinal valve; rectal gland cell; and spermatheca. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Is an ortholog of human CYLD (CYLD lysine 63 deubiquitinase).
- CYLD [Search on AGR]
Homo sapiens This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Foxe1 [Search on AGR]
Homo sapiens This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
- CYLD [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including deubiquitinase activity; proline-rich region binding activity; and zinc ion binding activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation protein catabolic process at postsynapse. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase); PARTICIPATES IN nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide.
- Foxe1 [Search on AGR]
Rattus norvegicus Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including hard palate development; regulation of DNA-templated transcription; and soft palate development. Predicted to act upstream of or within several processes, including hair follicle morphogenesis; thyroid gland development; and thyroid hormone generation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and papillary thyroid carcinoma. Orthologous to human FOXE1 (forkhead box E1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.