smc-3

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity. Involved in establishment of mitotic sister chromatid cohesion. Located in chromatin and nucleus. Part of MIS12/MIND type complex and cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Is an ortholog of human SMC3 (structural maintenance of chromosomes 3).

T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

scc-2

Caenorhabditis elegans

Enables cohesin loader activity. Involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process. Located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is an ortholog of human NIPBL (NIPBL cohesin loading factor).

gst-35

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

W10C8.4

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

gst-34

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

msra-1

Caenorhabditis elegans

Enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in cytoplasm. Expressed in hypodermis and neurons. Is an ortholog of human MSRA (methionine sulfoxide reductase A).

slc-25A26

Caenorhabditis elegans

Enables S-adenosyl-L-methionine transmembrane transporter activity. Involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Is an ortholog of human SLC25A26 (solute carrier family 25 member 26).

him-1

Caenorhabditis elegans

Enables DNA binding activity. Involved in several processes, including chromosome segregation; establishment of mitotic sister chromatid cohesion; and response to radiation. Located in chromatin and nucleus. Part of MIS12/MIND type complex and cohesin complex. Expressed in linker cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Is an ortholog of human SMC1B (structural maintenance of chromosomes 1B).

coh-1

Caenorhabditis elegans

Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be located in chromosome and nucleus. Predicted to be part of cohesin complex. Expressed in several structures, including anterior distal tip cell; anterior gonad arm; germ line; and posterior distal tip cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1).