Osr2

Homo sapiens

OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

hmt-1

Caenorhabditis elegans

Enables cadmium ion transmembrane transporter activity. Involved in cadmium ion transmembrane transport; cellular detoxification of cadmium ion; and detoxification of copper ion. Located in endosome and vacuolar membrane. Expressed in coelomocyte; head neurons; intestinal cell; and tail neurons. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Is an ortholog of human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)).

Abcb6

Rattus norvegicus

Predicted to enable several functions, including ABC-type heme transporter activity; ATP binding activity; and ATP hydrolysis activity. Involved in intracellular copper ion homeostasis. Located in early endosome membrane; endolysosome membrane; and late endosome membrane. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; allethrin.

Abcb6

Homo sapiens

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. This protein is a member of the heavy metal importer subfamily and plays a role in porphyrin transport. This gene is the molecular basis of the Langereis (Lan) blood group antigen and mutations in this gene underlie familial pseudohyperkalemia and dyschromatosis universalis hereditaria. [provided by RefSeq, Mar 2017]