PHENOTYPE: Homozygous KO reduces competitiveness of T cells with wild-type in spleen and thymus in a chimeric bone marrow transplantation model. KO in conjunction with Gimap5 KO exacerbates the reduction in T cell numbers in spleen and lymph nodes of Gimap5 single-KO. [provided by MGI curators]
Predicted to be involved in signal transduction. Is an ortholog of human TCP11 (t-complex 11); TCP11L1 (t-complex 11 like 1); and TCP11L2 (t-complex 11 like 2).
Predicted to enable several functions, including ATP binding activity; helicase activity; and nucleic acid binding activity. Predicted to be located in cytoplasm. Is an ortholog of human DDX60 (DExD/H-box helicase 60) and DDX60L (DExD/H-box 60 like).
Predicted to enable box H/ACA snoRNA binding activity. Predicted to be involved in snoRNA guided rRNA pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Is an ortholog of human GAR1 (GAR1 ribonucleoprotein).
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in regulation of T cell activation and regulation of T cell migration. Predicted to be located in membrane.
Is affected by clk-1 and etr-1 based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Serpentine type 7TM GPCR chemoreceptor Srh; 7TM GPCR, serpentine receptor class h (Srh); and Nematode receptor-like serpentine class H.
Predicted to enable unfolded protein binding activity. Predicted to be involved in box H/ACA snoRNP assembly. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia. Is an ortholog of human SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor).
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is an ortholog of human ATP6V1H (ATPase H+ transporting V1 subunit H).