ktub

Drosophila melanogaster

king tubby (ktub) encodes a protein that belongs to the tubby and tubby-like protein family. It functions in endocytosis of the rhodopsin encoded by ninaE, retinal degeneration upon light stimulation, and the localization of channel encoded by the channel encoded by trp in cilia.

M01A12.4

Caenorhabditis elegans

Predicted to enable protein tyrosine phosphatase activity. Is an ortholog of human PTPRR (protein tyrosine phosphatase receptor type R).

hrpr-1

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Located in nucleus. Expressed widely. Is an ortholog of human HNRNPR (heterogeneous nuclear ribonucleoprotein R) and SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein).

str-35

Caenorhabditis elegans

Is affected by clk-1 and sir-2.1 based on microarray studies. Is predicted to encode a protein with the following domains: 7TM GPCR, serpentine receptor class r (Str) and Serpentine type 7TM GPCR chemoreceptor Str.

Bdh1

Saccharomyces cerevisiae

NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source

zig-4

Caenorhabditis elegans

Involved in neuron development. Predicted to be located in extracellular region. Expressed in neurons and pharynx.

Y45G12C.6

Caenorhabditis elegans

Is affected by several genes including cyc-1; clk-1; and lin-15B based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: 7TM GPCR, serpentine receptor class r (Str) and Serpentine type 7TM GPCR chemoreceptor Str.

flp-8

Caenorhabditis elegans

Involved in negative regulation of turning behavior involved in mating. Predicted to be located in extracellular region. Expressed in PVM; head; nerve ring; and tail.

F44E2.6

Caenorhabditis elegans

Predicted to enable peptide-methionine (R)-S-oxide reductase activity. Predicted to be involved in protein repair and response to oxidative stress. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Is an ortholog of human MSRB2 (methionine sulfoxide reductase B2).

r

Drosophila melanogaster

rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy.