- Hk [Search on AGR]
Drosophila melanogaster Hyperkinetic (Hk) encodes a beta-subunit of Sh K[+] channels and modulates its channel function. It is important in regulating action potentials in neurons and muscles, and transmitter release.
- Shab [Search on AGR]
Drosophila melanogaster Shaker cognate b (Shab) encodes a member of the Sh family and the structural alpha subunit of a delayed rectifier K[+] channel (Kv2). The product of Shab channel functions to regulate excitability in neurons and muscles, and transmitter release.
- Sh [Search on AGR]
Drosophila melanogaster Shaker (Sh) encodes the structural alpha subunit of a voltage-gated potassium channel. It plays a key role in maintaining electrical excitability in neurons and muscle cells, as well as regulating neurotransmitter release at the synapse.
- Glis1 [Search on AGR]
Homo sapiens GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]
- Adig [Search on AGR]
Homo sapiens ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]
- qvr [Search on AGR]
Drosophila melanogaster quiver (qvr) encodes a Ly-6 protein. Ly-6 proteins are GPI-linked or secreted proteins that modulate the trafficking and/or activity of membrane protein targets, including the potassium channel encoded by Sh and nicotinic acetylcholine receptors.
- ced-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables clathrin adaptor activity and scavenger receptor binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in cytoplasmic side of plasma membrane and phagocytic vesicle. Is an ortholog of human GULP1 (GULP PTB domain containing engulfment adaptor 1).
- Cerk [Search on AGR]
Homo sapiens CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
- Son [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mice die before E6.5-7.5. Heterozygous mice model Zhu-Tokita-Takenouchi-Kim syndrome, with growth retardation, cognitive impairment, skeletal abnormalities, kidney agenesis, hematopoietic abnormalities including leukopenia and immunoglobulin deficiency and impaired erythropoiesis. [provided by MGI curators]
- ced-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Involved in several processes, including engulfment of apoptotic cell; positive regulation of distal tip cell migration; and positive regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); chronic myeloid leukemia; and invasive ductal carcinoma. Is an ortholog of human CRK (CRK proto-oncogene, adaptor protein) and CRKL (CRK like proto-oncogene, adaptor protein).