dpl-1

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including gonad development; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Located in nucleus. Expressed in germ line; gonad; and hyp7 syncytium. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Is an ortholog of human TFDP1 (transcription factor Dp-1); TFDP2 (transcription factor Dp-2); and TFDP3 (transcription factor Dp family member 3).

Dp

Drosophila melanogaster

DP transcription factor (Dp) encodes a member of the DREAM complex and the common subunit of the two Drosophila heterodimeric E2F transcription factors. It is regulated by the product of Rbf and the Cyclin dependent kinases and controls the transcription of genes necessary for cell cycle progression.

K03A11.1

Caenorhabditis elegans

Enriched in ADE sheath cell; B cell; BAG; hypodermis; and oocyte based on tiling array; single-cell RNA-seq; and RNA-seq studies. Is affected by several genes including cyc-1; swsn-1; and puf-8 based on microarray; tiling array; and RNA-seq studies. Is affected by twenty-four chemicals including methylmercuric chloride; D-glucose; and iron oxide nanoparticle based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domain: E2F-DP heterodimerization region.

mcd-1

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Involved in nematode larval development; positive regulation of growth rate; and programmed cell death.

Tfdp2

Homo sapiens

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

lin-52

Drosophila melanogaster

lin-52 (lin-52) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle.

mip130

Drosophila melanogaster

Myb-interacting protein 130 (mip130) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle.

mip40

Drosophila melanogaster

Myb-interacting protein 40 (mip40) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle.

Caf1-55

Drosophila melanogaster

Chromatin assembly factor 1, p55 subunit (Caf1-55) encodes a subunit of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle.

mip120

Drosophila melanogaster

Myb-interacting protein 120 (mip120) encodes the sequence-specific DNA-binding protein of the MuvB core complex. The MuvB core binds to the oncoprotein encoded by Myb and the Rbf-E2f2-Dp tumor suppressor complex, thereby controlling the expression of many genes, including critical regulators of the cell cycle.