- Bcl2a1 [Search on AGR]
Rattus norvegicus Enables BH domain binding activity. Involved in cerebral cortex development. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Orthologous to human BCL2A1 (BCL2 related protein A1); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
- pts [Search on AGR]
Homo sapiens The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]
- Pmaip1 [Search on AGR]
Homo sapiens This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]
- ced-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including BH domain binding activity; peptidase activator activity; and small molecule binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of synapse pruning; and regulation of apoptotic process. Located in several cellular components, including cytoplasm; membrane; and nucleus. Part of caspase complex. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in Parkinson's disease; lung non-small cell carcinoma; and pancreatic cancer. Is an ortholog of human APAF1 (apoptotic peptidase activating factor 1).
- Bik [Search on AGR]
Rattus norvegicus Enables BH domain binding activity. Predicted to be involved in several processes, including apoptotic mitochondrial changes; male gonad development; and positive regulation of cellular component organization. Predicted to act upstream of or within spermatogenesis. Predicted to be located in mitochondrial envelope. Predicted to be part of Bcl-2 family protein complex. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
- Bcl2l2 [Search on AGR]
Rattus norvegicus Enables BH domain binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to several human genes including BCL2L2 (BCL2 like 2); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (-)-bornyl-caffeate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol.
- Bok [Search on AGR]
Rattus norvegicus Enables BH domain binding activity and protein heterodimerization activity. Involved in several processes, including male gonad development; oligodendrocyte differentiation; and positive regulation of apoptotic process. Predicted to be located in several cellular components, including bounding membrane of organelle; mitochondrial inner membrane; and trans-Golgi network membrane. Predicted to be active in mitochondrial outer membrane. Biomarker of hydrocephalus. Orthologous to human BOK (BCL2 family apoptosis regulator BOK); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
- Mcl1 [Search on AGR]
Rattus norvegicus Enables BH domain binding activity and protein dimerization activity. Involved in negative regulation of apoptotic process. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleus. Predicted to be part of Bcl-2 family protein complex. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member); PARTICIPATES IN intrinsic apoptotic pathway; hypoxia inducible factor pathway; interleukin-6 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
- Bax [Search on AGR]
Rattus norvegicus Enables BH domain binding activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including cellular response to hydrogen peroxide; mitochondrion organization; and response to ischemia. Located in mitochondrial outer membrane and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); heart disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator); PARTICIPATES IN intrinsic apoptotic pathway; ceramide signaling pathway; syndecan signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-sesamin.