jun-1

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).

kgb-2

Caenorhabditis elegans

Predicted to enable JUN kinase activity. Predicted to be involved in JNK cascade. Predicted to be located in cytoplasm and nucleus.

Y54F10BM.13

Caenorhabditis elegans

Predicted to enable JUN kinase phosphatase activity. Predicted to be located in cytoplasm. Is an ortholog of human DUSP19 (dual specificity phosphatase 19).

sek-6

Caenorhabditis elegans

Predicted to enable JUN kinase kinase activity. Predicted to be involved in MAPK cascade. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K4 (mitogen-activated protein kinase kinase 4).

fs(1)Ya

Drosophila melanogaster

female sterile (1) Young arrest (fs(1)Ya) encodes a maternally-expressed protein that is required for mitotic phase initiation during early embryogenesis. It localizes in the nuclear lamina of the embryo, and binds DNA and the product of His2B. In developing oocytes the product of fs(1)Ya is cytoplasmic, but enters nuclei when it is dephosphorylated during egg activation.

Jra

Drosophila melanogaster

Jun-related antigen (Jra) encodes a homologue of the mammalian transcription factor Jun and has pleiotropic roles in the CNS. Jra activity is regulated by many upstream enzymes, including bsk.

OVOC10523

Onchocerca volvulus

Is predicted to encode a protein with the following domain: Jun-like transcription factor.

glh-4

Caenorhabditis elegans

Enables JUN kinase binding activity. Involved in gamete generation and regulation of cell population proliferation. Located in P granule.

Map3k21

Rattus norvegicus

Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in MAPK cascade. Orthologous to human MAP3K21 (mitogen-activated protein kinase kinase kinase 21); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH alpha-Zearalanol; bisphenol A; methoxychlor.

glh-3

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity and JUN kinase binding activity. Predicted to be involved in germ cell development. Located in P granule. Expressed in gonad. Is an ortholog of human DDX4 (DEAD-box helicase 4).