Gli2 [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and zinc ion binding activity. Involved in positive regulation of collagen biosynthetic process; prostate gland development; and response to mechanical stimulus. Predicted to be located in several cellular components, including axoneme; ciliary tip; and nuclear lumen. Predicted to be active in nucleus. Biomarker of esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.
tra-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in developmental process involved in reproduction; negative regulation of transcription by RNA polymerase II; and positive regulation of neuron apoptotic process. Located in cytoplasm and nucleus. Expressed in several structures, including AWA; germ line; gonad; intestine; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; gastrointestinal system cancer (multiple); and synostosis (multiple). Is an ortholog of human GLI1 (GLI family zinc finger 1); GLI2 (GLI family zinc finger 2); and GLI3 (GLI family zinc finger 3).